Long-term immune and epigenetic dysregulation following COVID-19

2025/12/13 by Chrysanthi Sidiropoulou, Garyphallia Poulakou, Evdoxia Kyriazopoulou +46 · 2 voices · 1 citation
Immunology and Microbiology · Medicine · #COVID-19 Clinical Research Studies #Downregulation and upregulation #Epigenetics #Epigenomics #Immune dysregulation #Immune system #Long-Term Effects of COVID-19 #Phenotype #Psoriasis: Treatment and Pathogenesis #Transcriptome

paper · doi:10.1016/j.clim.2025.110656

openalex created_date 2025/12/13 · openalex publication_date 2025/12/13 · openalex updated_date 2026/07/25

Abstract

) were upregulated in PACS patients. Respiratory phenotype was correlated with IL-1 upregulation (OR 4.23; 95 % CIs, 1.69-10.8, p = 0.0025). Transcriptomic and epigenomic changes were observed. Distinct phenotypes of PACS are driven by different immunological mechanisms at the DNA, transcriptomic, and protein levels.

Cited by

• Dynamic impacts of COVID-19 on immune cells and inflammatory indicators in Chinese medical health workers: a retrospective longitudinal study. [europepmc]

Discussions

• For those up the back?? Immune dysregulation is a considerable and unpleasant consequence of Cövid doi.org/10.1016/j.cl... [bsky, 128 points, 2 comments]
• Long-term immune and epigenetic dysregulation following COVID-19. Chrysanthi Sidiropoulou, et al. Clinical Immunology, 2026. doi.org/10.1016/j.cl... [bsky, 0 points, 0 comments]

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