2013/06/19 by Hongzhi Lan, Soojung Hur, Lan, Hongzhi +6
Biochemistry, Genetics and Molecular Biology · Engineering · Physics and Astronomy · #3D Printing in Biomedical Research #Cell Behavior (q-bio.CB) #Cellular Mechanics and Interactions #FOS: Biological sciences #FOS: Physical sciences #Fluid Dynamics (physics.flu-dyn) #Microfluidic and Bio-sensing Technologies #Soft Condensed Matter (cond-mat.soft) #cond-mat.soft #physics.flu-dyn #q-bio.CB
paper · pdf · doi:10.48550/arxiv.1306.4709
20 pages, 4 figures, submitted to Biorheology
arxiv created 2013/06/19 · openalex publication_date 2013/06/19 · arxiv updated 2013/06/21 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28
The effects of cell size and deformability on the lateral migration and deformation of living cells flowing through a rectangular microchannel has been numerically investigated and compared with the inertial-microfluidics data on detection and separation of cells. The results of this work indicate that the cells move closer to the centerline if they are bigger and/or more deformable and that their equilibrium position is largely determined by the solvent (cytosol) viscosity, which is much less than the polymer (cytoskeleton) viscosity measured in most rheological systems. Simulations also suggest that decreasing channel dimensions leads to larger differences in equilibrium position for particles of different viscoelastic properties, giving design guidance for the next generation of microfluidic cell separation chips.