Protein fitness prediction with language models

2026/07/13 by Tong Wang
Social Sciences · Biochemistry, Genetics and Molecular Biology · #Language and cultural evolution #Machine Learning in Bioinformatics #Bioinformatics and Genomic Networks

paper · doi:10.1038/s43588-026-01011-y

Abstract

Nature Computational Science, Published online: 13 July 2026; doi:10.1038/s43588-026-01011-y Protein language models are powerful computational tools for protein fitness prediction. The recent investigation into the relationship between model outputs and prediction accuracy reveals the scaling behavior of such models and provides practical guidelines for their applications to fitness prediction.

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