Anti-inflammatory and Antioxidant Activity Screening for New Steroidal Schiff Bases

2023/08/01 by Selman, N. A. Samad, Abbas, L. J., Abdullah, A. S.
#Anti-inflammatory #Antioxidant #Cholesterol #Ergosterol #Schiff bases #Steroidal derivatives

paper · doi:10.48317/imist.prsm/morjchem-v11i04.40231

Abstract

In the present work, two aldehyde derivatives were synthesized one from cholesterol and one from ergosterol and further condensed with three different primary amines (2-amino 6-fluoro benzathiazole, thiosemicarbazide, carbohydrazide) to yield the corresponding Schiff’s bases. The synthesized compounds were verified using spectral analysis, including IR, 1H-NMR, and GC Mass, and were tested for antioxidant and anti-inflammatory properties. From the synthetic materials, three to four compounds showed significant anti-inflammatory and antioxidant activities.

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