Synthesis, identification, thermal analysis, computational, and antibacterial studies of Z-N'-(5-bromothiophen-2-yl)methylene)nicotinohydrazide

2015/12/09 by Yahya Hussam, Ahmad Abu-Obaid, Hussam, Yahya +13
Chemistry · #DFT. #FT-IR #Inorganic and Organometallic Chemistry #Schiff bases #Synthesis and Characterization of Heterocyclic Compounds #Synthesis and biological activity #TG #condensation

paper · doi:10.48317/imist.prsm/morjchem-v4i1.4183

openalex publication_date 2015/12/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/01

Abstract

N'-((5-bromothiophen-2-yl)methylene)nicotinohydrazide Schiff base was isolated and characterized as Z-isomer. Ethanoic reflux condensation of equivalent amount of nicotinohydrazideand with 5-bromothiophene-2-carbaldehyde produced the desired compound in good yield. The condensation reaction was monitored by FT-IR and UV-visible as well as DFT calculation. The structure of desired compound wasexperimentally analyzed based on: elemental analysis, EI-Ms, UV-visible, FT-IR spectral, TG/DTG and 1H-NMR.DFT-computational calculation supportedZ- isomer as favorited product over E one, good accordance between experimental and theoretical calculated were recorded. The antibacterial results obtained using the desired compound indicates a promising result against human pathogenic bacteria.

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