The motility-matrix production switch in Bacillus subtilis -- a modeling perspective

2023/08/24 by Simon Dannenberg, Dannenberg, Simon, Jonas Penning +5 · 1 voice
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #physics.bio-ph #nlin.CD #q-bio.CB #q-bio.MN #q-bio.QM

paper · pdf · doi:10.48550/arxiv.2308.12780

Abstract

Phenotype switching can be triggered by external stimuli and by intrinsic stochasticity. Here, we focus on the motility-matrix production switch in Bacillus subtilis. We use modeling to describe the SinR-SlrR bistable switch its regulation by SinI, and to distinguish different sources of stochasticity. Our simulations indicate that intrinsic fluctuations in the synthesis of SinI are insufficient to drive spontaneous switching and suggest that switching is triggered by upstream noise from the Spo0A phosphorelay.

Discussions

• The motility-matrix production switch in Bacillus subtilis -- a modeling perspective arXiv from Stefan Klumpp arxiv.org/abs/2308.127... [bsky, 12 points, 0 comments]

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