Therapeutic drug monitoring of β-lactams for critically ill patients: unwarranted or essential?

2010/03/02 by Jason A. Roberts, William W. Hope, William Hope +1 · 17 citations
Medicine · Immunology and Microbiology · #Antibiotics Pharmacokinetics and Efficacy #Pneumonia and Respiratory Infections #Antibiotic Use and Resistance

paper · doi:10.1016/j.ijantimicag.2010.01.022

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• Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review. [europepmc]
• Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used? [europepmc]
• Individualization of piperacillin dosing for critically ill patients: dosing software to optimize antimicrobial therapy. [europepmc]
• Antibiotic dosing in critically ill patients with septic shock and on continuous renal replacement therapy: can we resolve this problem with pharmacokinetic studies and dosing guidelines? [europepmc]
• The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study. [europepmc]
• Method Based on the β-Lactamase PenPC Fluorescent Labeled for β-Lactam Antibiotic Quantification in Human Plasma. [europepmc]
• Clinical Validation of Therapeutic Drug Monitoring of Imipenem in Spent Effluent in Critically Ill Patients Receiving Continuous Renal Replacement Therapy: A Pilot Study. [europepmc]
• Population Pharmacokinetics of Piperacillin in Sepsis Patients: Should Alternative Dosing Strategies Be Considered? [europepmc]
• Therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam to improve outcome in patients with sepsis (TARGET): a prospective, multi-centre, randomised controlled trial. [europepmc]
• Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT). [europepmc]
• Impact of Intraoperative Cell Salvage on Concentrations of Antibiotics Used for Surgical Prophylaxis. [europepmc]
• Pharmacodynamic Thresholds for Beta-Lactam Antibiotics: A Story of Mouse Versus Man. [europepmc]
• Comparison of pharmacokinetics software for therapeutic drug monitoring of piperacillin in patients with severe infections. [europepmc]
• Population pharmacokinetics and dosing optimisation of imipenem in critically ill patients. [europepmc]
• β -Lactam Pharmacokinetic/Pharmacodynamic Target Attainment in Intensive Care Unit Patients: A Prospective, Observational, Cohort Study. [europepmc]
• Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study. [europepmc]
• Therapeutic drug monitoring and the role of pharmacokinetics/pharmacodynamics in optimizing beta-lactam antibiotic dosing for deep-seated infections: a systematic review. [europepmc]