Bacteriophages and phage-delivered CRISPR-Cas system as antibacterial therapy

2021/11/09 by Ting-Kuang Yeh, Shio-Shin Jean, Yu-Lin Lee +10 · 42 citations
Biochemistry, Genetics and Molecular Biology · Environmental Science · #Advanced biosensing and bioanalysis techniques #Antibiotic resistance #Antibiotics #Antimicrobial #Bacteria #Bacteriophage #Bacteriophages and microbial interactions #Biology #CRISPR #CRISPR and Genetic Engineering #Computational biology #Escherichia coli #Gene #Genetics #Microbiology #Phage therapy #Virology

paper · doi:10.1016/j.ijantimicag.2021.106475

published in International Journal of Antimicrobial Agents 59(1), 106475 (Elsevier BV)

openalex publication_date 2021/11/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

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• CRISPR-Cas System: A Tool to Eliminate Drug-Resistant Gram-Negative Bacteria. [europepmc]
• CRISPR-Based Gene Editing in Acinetobacter baumannii to Combat Antimicrobial Resistance. [europepmc]
• CRISPR-Cas-Based Adaptive Immunity Mediates Phage Resistance in Periodontal Red Complex Pathogens. [europepmc]
• Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections. [europepmc]
• The overlooked bacterial pandemic. [europepmc]
• The Medicinal Phage-Regulatory Roadmap for Phage Therapy under EU Pharmaceutical Legislation. [europepmc]
• Bacteriophage as a potential biotherapeutics to combat present-day crisis of multi-drug resistant pathogens. [europepmc]
• Gene editing tool-loaded biomimetic cationic vesicles with highly efficient bacterial internalization for in vivo eradication of pathogens. [europepmc]
• Predicting phage-host interactions via feature augmentation and regional graph convolution. [europepmc]
• Pharmacodynamic Evaluation of Phage Therapy in Ameliorating ETEC-Induced Diarrhea in Mice Models. [europepmc]
• Reprogramming resistance: phage-antibiotic synergy targets efflux systems in ESKAPEE pathogens. [europepmc]
• The role of bacteriophages and CRISPR-Cas in combating multidrug-resistant bacteria. [europepmc]
• Bacteriophages: a double-edged sword in the gastrointestinal tract. [europepmc]
• Phage enabled precision drug delivery: dual function platforms for therapeutics and genetic cargo transport. [europepmc]
• CRISPR-Cas systems as next-generation antimicrobials: a systemic review of mechanisms, delivery strategies, and translational challenges. [europepmc]
• Infection-driven proliferative phase impairment in chronic wounds: a mechanistic framework for precision regenerative therapy. [europepmc]
• Efficacy and Safety Outcomes of Bacteriophage Therapy for Resistant Bacterial Infections. [europepmc]