2001/12/06 by Haijun Zhou, Zhou, Haijun
Biochemistry, Genetics and Molecular Biology · Engineering · Physics and Astronomy · #Advanced Materials and Mechanics #Elasticity and Material Modeling #FOS: Biological sciences #FOS: Physical sciences #Quantitative Biology (q-bio) #Soft Condensed Matter (cond-mat.soft) #Statistical Mechanics (cond-mat.stat-mech) #cond-mat.soft #cond-mat.stat-mech #q-bio
paper · pdf · doi:10.48550/arxiv.cond-mat/0112090
13 pages with 4 ps figures. Revised version. A serious mistake in the original version was corrected and new simulation data were included
openalex publication_date 2001/12/06 · arxiv created 2002/03/18 · arxiv updated 2009/11/30 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28
The stability of a β-sheeted conformation and its transition into a random coil are studied with a 2D lattice biopolymer model. At low temperature and low external force, the polymer folds back and forth on itself and forms a β-sheet. Our analytical calculation and Monte Carlo simulation reveal that a co-operative β-sheet--random coil transition takes places when the temperature or force is increased, with a dramatic decrease in the contact number. These predictions are in good agreement with experiments on titin protein. This transition is not a real phase-transition, indicating that backbone hydrogen-bonding alone is unable to stabilize a distinct β-sheet phase.