2014/04/15 by E. N. Bolbasov, M. Rybachuk, Bolbasov, E. N. +15
Physics and Astronomy · #Biological Physics (physics.bio-ph) #FOS: Physical sciences #Materials Science (cond-mat.mtrl-sci) #cond-mat.mtrl-sci #physics.bio-ph
paper · pdf · doi:10.48550/arxiv.1404.3794
11 pages, 2 figures, 2 tables
arxiv created 2014/04/15 · arxiv updated 2014/04/16
Surface modification of poly(L-lactide) (L-PLA) and polycaprolactone (PCL) bioresorbable polymers by radio-frequency thermal glow discharge plasma is reported. Improved biocompatibility of L-PLA and PCL materials was obtained by employing hydroxyapatite target sputtering in Ar+ plasma as evidenced by the change of L-PLA and PCL properties from highly hydrophobic to hydrophilic, with absolute wettability obtained for both materials, and enhanced endothelial hybrid cell line EA-hy 926 attachment to modified surfaces. For the latter, surface properties that suppress adverse cellular responses (e.g. apoptosis, necrosis) were also attained. Surface roughness and surface free energy were found to increase significantly for both polymers under prolonged plasma exposure and, a longer chain aliphatic PCL were found to display a marginally better post plasma-treated biocompatibility compared to L-PLA.