2020/06/13 by Michael Nosonovsky, Nosonovsky, Michael, Prosun Roy +1
Physics and Astronomy · #FOS: Physical sciences #Other Condensed Matter (cond-mat.other) #Soft Condensed Matter (cond-mat.soft) #cond-mat.other #cond-mat.soft
paper · pdf · doi:10.48550/arxiv.2006.07538
arxiv created 2020/06/13 · arxiv updated 2020/06/16
Allometry or the quantitative study of the relationship of body size to living organism physiology is an important area of biophysical scaling research. The West-Brown-Enquist (WBE) model of fractal branching in a vascular network explains the empirical allometric Kleiber law (the 3/4 scaling exponent for metabolic rates as a function of animal's mass). The WBE model raises a number of new questions, such as how to account for capillary phenomena more accurately and what are more realistic dependencies for blood flow velocity on the size of a capillary. We suggest a generalized formulation of the branching model and investigate the ergodicity in the fractal vascular system. In general, the fluid flow in such a system is not ergodic, and ergodicity breaking is attributed to the fractal structure of the network. Consequently, the fractal branching may be viewed as a source of ergodicity breaking in biophysical systems, in addition to such mechanisms as aging and macromolecular crowding. Accounting for non-ergodicity is important for a wide range of biomedical applications where long observations of time series are impractical. The relevance to microfluidics applications is also discussed.