Uso de herramientas Web 2.0 en los medios digitales de Ecuador

2001/03/01 by Catherine Gérard, C.M Gérard, N Baudson +15 · 11 citations
Computer Science · Social Sciences · #Media and Digital Communication #Communication and COVID-19 Impact #Journalism and Media Studies

paper · doi:10.1016/s0264-410x(00)00486-2

Abstract

Over 90% of cervical cancers are associated with HPV infection, the commonest being the HPV-16 subtype. Two early viral genes, E6 and 7, play major roles in the development and maintenance of the malignant phenotype. The vaccine potential of a recombinant HPV16 E7 protein was examined in two murine models of E7-expressing tumours. Formulations including the immunostimulants MPL and QS21 induced therapeutically active immune responses leading to regression of pre-established TC1 tumour lesions, associated with induction of IgG antibodies, lymphoproliferation and CTL. Our data provide a clear incentive to investigate the clinical application of this approach in cancer immunotherapy.

Cited by

• Recombinant Listeria Vaccines Containing PEST Sequences Are Potent Immune Adjuvants for the Tumor-Associated Antigen Human Papillomavirus-16 E7
• Development of HPV nanovaccine candidate based on IL-15-E7 fusion protein encapsulated in silk-fibroin nanoparticles
• Phase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia. [europepmc]
• Combined immunization with adjuvant molecules poly(I:C) and anti-CD40 plus a tumor antigen has potent prophylactic and therapeutic antitumor effects. [europepmc]
• Therapeutic HPV DNA vaccines. [europepmc]
• Therapeutic HPV DNA vaccines. [europepmc]
• Dendritic cell targeting vaccine for HPV-associated cancer. [europepmc]
• Bioproduction of a Therapeutic Vaccine Against Human Papillomavirus in Tomato Hairy Root Cultures. [europepmc]
• Vaccination Against Cervical Cancer: Hopes and Realities. [europepmc]
• Peptides for Vaccine Development. [europepmc]
• Global trends and hotspots on recurrent respiratory papillomatosis: A 20-year bibliometric analysis. [europepmc]

Related

• mRNA‐HPV vaccine encoding E6 and E7 improves therapeutic potential for HPV‐mediated cancers via subcutaneous immunization
• Development of a DNA Vaccine Targeting Human Papillomavirus Type 16 Oncoprotein E6
• Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
• HPV16-Expressing Tumors Release Multiple IL1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine
• Therapeutic efficacy of a human papillomavirus type 16 E7 bacterial exotoxin fusion protein adjuvanted with CpG or GPI-0100 in a preclinical mouse model for HPV-associated disease