Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994/09/09 by Edward W. Scott, M. Celeste Simon, John Anastasi +1 · 29 citations
Medicine · Immunology and Microbiology · #Acute Myeloid Leukemia Research #Cytokine Signaling Pathways and Interactions #Reproductive System and Pregnancy

paper · doi:10.1126/science.8079170

Abstract

The transcription factor PU.1 is a hematopoietic-specific member of the ets family. Mice carrying a mutation in the PU.1 locus were generated by gene targeting. Homozygous mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers of megakaryocytes and erythroid progenitors, but some showed an impairment of erythroblast maturation. An invariant consequence of the mutation was a multilineage defect in the generation of progenitors for B and T lymphocytes, monocytes, and granulocytes. Thus, the developmental programs of lymphoid and myeloid lineages require a common genetic function likely acting at the level of a multipotential progenitor.

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