Genomic insights into the evolutionary origin of Myxozoa within Cnidaria
2015/11/16 by E. Sally Chang, Moran Neuhof, Nimrod D. Rubinstein +4 · 32 citations
Biochemistry, Genetics and Molecular Biology · Environmental Science · #Myxozoan Parasites in Aquatic Species #Marine Ecology and Invasive Species
paper · pdf · doi:10.1073/pnas.1511468112
Abstract
The Myxozoa comprise over 2,000 species of microscopic obligate parasites that use both invertebrate and vertebrate hosts as part of their life cycle. Although the evolutionary origin of myxozoans has been elusive, a close relationship with cnidarians, a group that includes corals, sea anemones, jellyfish, and hydroids, is supported by some phylogenetic studies and the observation that the distinctive myxozoan structure, the polar capsule, is remarkably similar to the stinging structures (nematocysts) in cnidarians. To gain insight into the extreme evolutionary transition from a free-living cnidarian to a microscopic endoparasite, we analyzed genomic and transcriptomic assemblies from two distantly related myxozoan species, Kudoa iwatai and Myxobolus cerebralis, and compared these to the transcriptome and genome of the less reduced cnidarian parasite, Polypodium hydriforme. A phylogenomic analysis, using for the first time to our knowledge, a taxonomic sampling that represents the breadth of myxozoan diversity, including four newly generated myxozoan assemblies, confirms that myxozoans are cnidarians and are a sister taxon to P. hydriforme. Estimations of genome size reveal that myxozoans have one of the smallest reported animal genomes. Gene enrichment analyses show depletion of expressed genes in categories related to development, cell differentiation, and cell-cell communication. In addition, a search for candidate genes indicates that myxozoans lack key elements of signaling pathways and transcriptional factors important for multicellular development. Our results suggest that the degeneration of the myxozoan body plan from a free-living cnidarian to a microscopic parasitic cnidarian was accompanied by extreme reduction in genome size and gene content.
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- Cnidaria [wikipedia]
- Myxozoan polar tubules display structural and functional variation. [europepmc]
- Origin of animal multicellularity: precursors, causes, consequences-the choanoflagellate/sponge transition, neurogenesis and the Cambrian explosion. [europepmc]
- Diversity of Cnidarian Muscles: Function, Anatomy, Development and Regeneration. [europepmc]
- Hierarchical complexity and the size limits of life. [europepmc]
- Ctenophore relationships and their placement as the sister group to all other animals. [europepmc]
- Embracing Uncertainty in Reconstructing Early Animal Evolution. [europepmc]
- The Origin of Animal Multicellularity and Cell Differentiation. [europepmc]
- Gene family innovation, conservation and loss on the animal stem lineage. [europepmc]
- Linear Mitochondrial Genome in Anthozoa (Cnidaria): A Case Study in Ceriantharia. [europepmc]
- Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts. [europepmc]
- Box, stalked, and upside-down? Draft genomes from diverse jellyfish (Cnidaria, Acraspeda) lineages: Alatina alata (Cubozoa), Calvadosia cruxmelitensis (Staurozoa), and Cassiopea xamachana (Scyphozoa). [europepmc]
- Transcriptome Characterization of Reverse Development in Turritopsis dohrnii (Hydrozoa, Cnidaria). [europepmc]
- The complex evolutionary history of sulfoxide synthase in ovothiol biosynthesis. [europepmc]
- A cnidarian parasite of salmon (Myxozoa: Henneguya ) lacks a mitochondrial genome. [europepmc]
- The Mnemiopsis Genome Project Portal: integrating new gene expression resources and improving data visualization. [europepmc]
- Jellyfish genomes reveal distinct homeobox gene clusters and conservation of small RNA processing. [europepmc]
- Transcriptomic Analysis of Four Cerianthid (Cnidaria, Ceriantharia) Venoms. [europepmc]
- A Review of Toxins from Cnidaria. [europepmc]
- Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters. [europepmc]
- The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition. [europepmc]
- Development of Fish Parasite Vaccines in the OMICs Era: Progress and Opportunities. [europepmc]
- Six-State Amino Acid Recoding is not an Effective Strategy to Offset Compositional Heterogeneity and Saturation in Phylogenetic Analyses. [europepmc]
- Relaxed selection underlies genome erosion in socially parasitic ant species. [europepmc]
- Nematostella vectensis , an Emerging Model for Deciphering the Molecular and Cellular Mechanisms Underlying Whole-Body Regeneration. [europepmc]
- The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes. [europepmc]
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