Le Commerce des illustrations de thèses dans la seconde moitié du XVIII siècle, quelques documents inédits

1994/05/01 by Yueguang Rong, Christina McPhee, Christina K. McPhee +10 · 27 citations
Social Sciences · Arts and Humanities · #Historical and Literary Studies #Historical and Literary Analyses #Historical Studies in Science

paper · doi:10.1073/pnas.1013800108

Abstract

Autophagy is a conserved cellular process to degrade and recycle cytoplasmic components. During autophagy, lysosomes fuse with an autophagosome to form an autolysosome. Sequestered components are degraded by lysosomal hydrolases and presumably released into the cytosol by lysosomal efflux permeases. Following starvation-induced autophagy, lysosome homeostasis is restored by autophagic lysosome reformation (ALR) requiring activation of the "target of rapamycin" (TOR) kinase. Spinster (Spin) encodes a putative lysosomal efflux permease with the hallmarks of a sugar transporter. Drosophila spin mutants accumulate lysosomal carbohydrates and enlarged lysosomes. Here we show that defects in spin lead to the accumulation of enlarged autolysosomes. We find that spin is essential for mTOR reactivation and lysosome reformation following prolonged starvation. Further, we demonstrate that the sugar transporter activity of Spin is essential for ALR.

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