2025/04/22 by Agi, Bravery, Alagbe-Briggs, Olubusola, Johnson, Uyoata
#MgSO4 #Postoperative Sore Throat #Tracheal Intubation
paper · doi:10.71637/tnhj.v25i1.1003
Background: Postoperative sore throat (POST) is an undesirable complication after general anaesthesia involving use of endotracheal tubes (ETT). Pharmacological agents via different routes have been used for prevention. This study compared two routes of magnesium sulphate (MgSO4) in reducing its incidence and severity. Methods: This was a prospective, randomized, double-blind, placebo-controlled study in 84 patients undergoing abdominal surgery under general anaesthesia with tracheal intubation. Patients were randomly allocated into three groups. Group I (n=28) patients were nebulised with 3mls of normal saline (NS) and received 30mg/kg of IV MgSO4 in 50mls of NS. Group II (n=28) patients were nebulised with 225mg (3mls) of isotonic MgSO4 and infused with 50mls of NS. Patients in control group III (n=28) were nebulised with 3mls of NS and infused with 50mls of NS. Postoperatively, incidence and severity of POST were assessed at 0hour, 1hour, 4hours and 24hours using a four-point scale. ETT cuff pressure in all patients was maintained at 25cmH2O. Descriptive and inferential analysis were conducted using SPSS v.22 and presented as frequencies and percentages. Results: There were 84 patients with M:F ratio of 1:1.6 and mean age of 35.7±10.9years. Overall incidence of POST was 25(30.1%), but 3(11.1%), 7(25.0%), and 15(53.6%) in Groups I, II and III respectively. Severity was worse in the control group (p=0.002). No statistical difference occurred between nebulised and intravenous Groups (p = 0.324) Conclusion: Intravenous and nebulised routes of MgSO4 have comparable effects in reducing incidence and severity of POST.