Free boundary limits of coupled bulk-surface models for receptor-ligand interactions on evolving domains

2024/07/23 by Alphonse, Amal, Caetano, Diogo, Elliott, Charles M. +1 · 1 citation
#Analysis of PDEs (math.AP) #FOS: Mathematics

paper · doi:10.48550/arxiv.2407.16522

Abstract

We derive various novel free boundary problems as limits of a coupled bulk-surface reaction-diffusion system modelling ligand-receptor dynamics on evolving domains. These limiting free boundary problems may be formulated as Stefan-type problems on an evolving hypersurface. Our results are new even in the setting where there is no domain evolution. The models are of particular relevance to a number of applications in cell biology. The analysis utilises L^∞-estimates in the manner of De Giorgi iterations and other technical tools, all in an evolving setting. We also report on numerical simulations.

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