Study of linear energy transfer effect on rib fracture in breast patients receiving pencil-beam-scanning proton therapy

2023/10/31 by Yunze Yang, Yang, Yunze, Kimberly R. Gergelis +19
Medicine · Physics and Astronomy · #Advanced Radiotherapy Techniques #Effects of Radiation Exposure #FOS: Physical sciences #Medical Physics (physics.med-ph) #Radiation Therapy and Dosimetry

paper · doi:10.48550/arxiv.2310.20527

openalex publication_date 2023/10/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Purpose: To study the effect of proton linear energy transfer (LET) on rib fracture in breast cancer patients treated with pencil-beam scanning proton therapy (PBS) using a novel tool of dose-LET volume histogram (DLVH). Methods: -value map derived from CLR model, the DLVH features associated with the patient outcomes were extracted. Results: value for V(30 Gy[RBE], 4.0 keV/um) was 0.069. Conclusions: In breast cancer patients receiving PBS, a larger volume of chest wall receiving moderate dose and high LET may result in increased risk of rib fracture.

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