2018/03/09 by Peshala Thibbotuwawa Gamage, Gamage, Peshala P. T, Fardin Khalili +3
Medicine · #Cardiovascular Health and Disease Prevention #Coronary Interventions and Diagnostics #Advanced MRI Techniques and Applications
paper · pdf · doi:10.48550/arxiv.1803.03554
As the heart beats, it creates fluctuation in blood pressure leading to a\npulse wave that propagates by displacing the arterial wall. These waves travel\nthrough the arterial tree and carry information about the medium that they\npropagate through as well as information of the geometry of the arterial tree.\nPulse wave velocity (PWV) can be used as a non-invasive diagnostic tool to\nstudy the functioning of cardiovascular system. A stenosis in an artery can\ndampen the pulse wave leading to changes in the propagating pulse. Hence, PWV\nanalysis can be performed to detect a stenosed region in arteries. This paper\npresents a numerical study of pulse wave propagation in a stenosed artery by\nmeans of two-way coupled fluid structure interaction (FSI). The computational\nmodel was validated by the comparison of the simulated PWV results with\ntheoretical values for a healthy artery. Propagation of the pulse waves in the\nstenosed artery was compared with healthy case using spatiotemporal maps of\nwall displacements. The analysis for PWV showed significance differences\nbetween the healthy and stenosed arteries including damping of propagating\nwaves and generation of high wall displacements downstream the stenosis caused\nby flow instabilities. This approach can be used to develop patient-specific\nmodels that are capable of predicting PWV signatures associated with stenosis\nchanges. The knowledge gained from these models may increase utility of this\napproach for managing patients at risk of stenosis occurrence.\n