Modeling deep brain stimulation effects in native patient or template space - Does it matter?

2025/05/06 by Julianna Pijar, Lukas L. Goede, Konstantin Butenko +9 · 1 voice · 1 citation
Medicine · Neuroscience · #Neurological disorders and treatments #Functional Brain Connectivity Studies #EEG and Brain-Computer Interfaces

paper · pdf · doi:10.1016/j.brs.2025.05.004

Abstract

Deep Brain Stimulation (DBS) has emerged as a transformative therapy for neurological disorders. Advanced methods allow group-level analyses of lead reconstructions and stimulation volumes to identify brain regions associated with optimal therapeutic benefit. However, this presents a challenge in relating patient-specific anatomy to a standardized template, as non-linear transformations are required, which can introduce inaccuracies1

Cited by

• Robustness of Lead Reconstruction for Deep Brain Stimulation Modeling and Probabilistic Mapping

Discussions

• When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in t [bsky, 15 points, 0 comments]

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