Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

2024/11/29 by Zhouyi Rong, Hongcheng Mai, Gregor Ebert +54 · 4 voices · 12 citations
Medicine · Neuroscience · #Long-Term Effects of COVID-19 #Neuroinflammation and Neurodegeneration Mechanisms #Infectious Encephalopathies and Encephalitis

paper · doi:10.1016/j.chom.2024.11.007

Citations

• Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
• SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology
• SARS-CoV-2 is associated with changes in brain structure in UK Biobank
• Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice

Cited by

• Post-acute sequelae of COVID-19: A disorder of impaired innate immune resolution – A narrative review
• SARS-CoV-2 spike protein causes synaptic dysfunction and p-tau and α-synuclein aggregation leading cognitive impairment: The protective role of metformin
• SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes
• COVID-19 Is Airborne AIDS: Provocative Oversimplification, Emerging Science, or Something in Between?
• Insights into Persistent SARS-CoV-2 Reservoirs in Chronic Long COVID
• Neuroimmune pathophysiology of long COVID
• Overview and Pathophysiology of Long COVID
• Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID
• Exploring the long‐term effects of COVID‐19 in patients with epilepsy: A multicenter Italian observational study
• Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-Synuclein accumulation in brain regions relevant to Parkinson’s disease
• Designing studies for post-treatment Lyme disease and other infection-associated chronic illnesses
• No evidence of direct activation of human neutrophil responses by multivalent prefusion trimeric SARS-CoV-2 Spike protein ex vivo

Discussions

• A fantastic new study in @cp-cellhostmicrobe.bsky.social led by @erturklab.bsky.social reveals that SARS-CoV-2 S1 protein can accumulate in the brain for years, potentially contributing to #LongCOVI [bsky, 15 points, 1 comments]
• Long COVID Breakthrough: Spike Proteins Persist in Brain for Years BY HELMHOLTZ ZENTRUM MÜNCHENJANUARY 6, 2025 doi.org/10.1016/j.ch... [bsky, 3 points, 0 comments]
• Some of the imaging from a 2024 article in Cell Host & Microbe doi.org/10.1016/j.ch... [bsky, 0 points, 1 comments]
• Probably Not Just A Cold Department... Rong et al., Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19, Cell Host & Microbe (2024), [bsky, 0 points, 0 comments]