A DNA language model based on multispecies alignment predicts the effects of genome-wide variants

2025/01/02 by Gonzalo Benegas, Carlos Albors, Alan J. Aw +2 · 2 voices · 8 citations
Biochemistry, Genetics and Molecular Biology · #Genomics and Rare Diseases #Genomics and Phylogenetic Studies #Genetic Associations and Epidemiology

paper · doi:10.1038/s41587-024-02511-w

Citations

• Rare-Variant Association Analysis: Study Designs and Statistical Tests

Cited by

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• Understanding and Enhancing Mask-Based Pretraining towards Universal Representations
• Genome modeling and design across all domains of life with Evo 2
• Transformers and genome language models

Discussions

• Happy New Year! Our GPN-MSA paper is finally published, under a slightly different title from the preprint. Please check it out and share it with your colleagues: doi.org/10.1038/s415... 1/4 [bsky, 16 points, 1 comments]
• "A DNA language model based on multispecies alignment predicts the effects of genome-wide variants" Benegas G, Albors C, Aw AJ, Ye C, Song YS. Nat Biotechnol. 2025-01-02. doi.org/10.1038/s415... GPN-M [bsky, 0 points, 0 comments]