Conservation and diversification of MHC class I and its related molecules in vertebrates

1999/02/01 by Keiichiro Hashimoto, Kazuhiko Okamura, Hisateru Yamaguchi +3 · 2 citations
Immunology and Microbiology · #Immune Cell Function and Interaction #Reproductive System and Pregnancy #T-cell and B-cell Immunology

paper · doi:10.1111/j.1600-065x.1999.tb01384.x

openalex publication_date 1999/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15

Abstract

The elucidation of the complete peptide-binding domains of the highly polymorphic shark MHC class I genes offered us an opportunity to examine the characteristics of their predicted protein products in the light of the latest advance in the structural studies of the MHC class I molecules. The results suggest that the fundamental characteristics in the T-cell recognition of the MHC class I molecule/peptide complex are expected to have been established at the early stage of the vertebrate evolution. The elucidation of the typical classical class I molecules from fishes and also of some MHC class I-related molecules may help us-to explore the common denominator of the ancient class I molecules.

Citations

• Class I Mhc genes of cichlid fishes: identification, expression, and polymorphism
• Identification of major histocompatibility complex genes in the guppy, Poecilia reticulata

Cited by

• Deciphering small sequence differences in T cell receptor-antigen pairing
• HFE gene: Structure, function, mutations, and associated iron abnormalities

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