Mathematical modeling of within‐host Zika virus dynamics

2018/08/11 by Katharine Best, Alan S. Perelson, Alan S Perelson · 1 citation
Mathematics · Medicine · #COVID-19 epidemiological studies #Mosquito-borne diseases and control #Viral Infections and Vectors

paper · pdf · doi:10.1111/imr.12687

openalex publication_date 2018/08/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Recent Zika virus outbreaks have been associated with severe outcomes, especially during pregnancy. A great deal of effort has been put toward understanding this virus, particularly the immune mechanisms responsible for rapid viral control in the majority of infections. Identifying and understanding the key mechanisms of immune control will provide the foundation for the development of effective vaccines and antiviral therapy. Here, we outline a mathematical modeling approach for analyzing the within-host dynamics of Zika virus, and we describe how these models can be used to understand key aspects of the viral life cycle and to predict antiviral efficacy.

Citations

• Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
• On Identifiability of Nonlinear ODE Models and Applications in Viral Dynamics

Cited by

• A multiscale framework integrating within-host infection kinetics with airborne transmission dynamics

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