2015/10/26 by Andrew Getahun, John C. Cambier · 3 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Galectins and Cancer Biology #Glycosylation and Glycoproteins Research #Protein Tyrosine Phosphatases
paper · doi:10.1111/imr.12336
openalex publication_date 2015/10/26 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/29
Receptors for immunoglobulin Fc regions play multiple critical roles in the immune system, mediating functions as diverse as phagocytosis, triggering degranulation of basophils and mast cells, promoting immunoglobulin class switching, and preventing excessive activation. Transmembrane signaling associated with these functions is mediated primarily by two amino acid sequence motifs, ITAMs (immunoreceptor tyrosine-based activation motifs) and ITIMs (immunoreceptor tyrosine-based inhibition motifs) that act as the receptors' interface with activating and inhibitory signaling pathways, respectively. While ITAMs mobilize activating tyrosine kinases and their consorts, ITIMs mobilize opposing tyrosine and inositol-lipid phosphatases. In this review, we will discuss our current understanding of signaling by these receptors/motifs and their sometimes blurred lines of function.