2017/01/01 by Jacqueline de Souza, Maria do Nascimento, Maria Paula Gonçalves Borsodi +8
Biochemistry, Genetics and Molecular Biology · #Traditional and Medicinal Uses of Annonaceae
paper · pdf · doi:10.21577/0103-5053.20170228
Poincianella pluviosa is a tree whose stem bark is reputed to have antidiarrheal, wound healing, antitumoral and antimalarial properties. Considering that the leaves of the tree are a more abundant and renewable source than the stem bark, we chose to study the antimalarial potential of this organ part. The aqueous leaf extract exhibited a rich phenolic profile. It was active (IC 50 = 6.88 1.64 g mL -1 ) against chloroquine resistant Plasmodium falciparum (W2) without toxicity to HepG2 A16 cells. The organic fraction was more active (IC 50 = 1.83 g mL -1 ) than the aqueous leaf extract itself. Ten phenolic compounds were obtained from the latter. This is the first report on the phenolic composition of P. pluviosa leaves. Ellagic acid (IC 50 = 0.215 0.007 g mL -1 ) proved to be 32 fold more active than the aqueous leaf extract itself. Considering their renewable aspect, leaves of P. pluviosa appear to be a more interesting source of antimalarial compounds than stem bark.