Microwave-assisted Passerini reactions under solvent-free conditions

2011/03/01 by Angélica de Fátima S Barreto, Angélica de Fátima S. Barreto, Otilie E Vercillo +3 · 35 citations
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Aldehyde #Bioactive Compounds and Antitumor Agents #Catalysis #Chemistry #Combinatorial chemistry #Computer science #Microwave #Microwave irradiation #Microwave-Assisted Synthesis and Applications #Multicomponent Synthesis of Heterocycles #Organic chemistry #Reaction conditions #Solvent

paper · pdf · doi:10.1590/s0103-50532011000300008

published in Journal of the Brazilian Chemical Society 22(3), 462-467 (Brazilian Chemical Society)

openalex publication_date 2011/03/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/04

Abstract

Various α-acyloxy carboxyamides were easily obtained combining three building blocks in one step: a carboxylic acid, an aldehyde and an isonitrile (Passerini reaction), using microwave irradiation under solvent-free conditions. The products were obtained in good yields (61-90%) and in short reaction times (< 5 min), using two different temperatures (60 and 120 ºC). At 120 ºC, the yields were higher and the reactions faster (< 1 min). Most of the obtained products are multifunctional allowing their application in consecutive Passerini reactions

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