Green Synthesis of Chalcones and Microbiological Evaluation

2015/01/01 by Marina Ritter, Rosiane Mastelari Martins, Rosiane M. Martins +8
Chemistry · #Multicomponent Synthesis of Heterocycles #Synthesis and Biological Evaluation #Synthesis and biological activity

paper · doi:10.5935/0103-5053.20150084

openalex publication_date 2015/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

A green method was developed for the synthesis of chalcones using glycerin as solvent. Subsequently, the potential microbiology activity of these molecules was evaluated by testing them against the Gram-positive bacteria Staphylococcus aureus (S. aureus) ATCC 19095 and Enterococcus faecalis (E. faecalis) ATCC 4083, the Gram-negative bacteria Escherichia coli (E. coli) ATCC 29214 and Pseudomonas aeruginosa (P. aeruginosa) ATCC 9027, and the fungus Candida albicans (C. albicans), which includes ATCC 62342 and three clinical strains of C. albicans from human oral cavities. The results showed that some chalcones exhibited moderate inhibitory activity, the most prominent being those acting against the fluconazole-resistant strains of C. albicans.

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