Human Urine Alters Methicillin-Resistant Staphylococcus aureus Virulence and Transcriptome

2021/06/09 by Santosh Paudel, Kamal Bagale, Swapnil Patel +2 · 1 citation
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Medicine · #Antimicrobial Resistance in Staphylococcus #Bacterial Identification and Susceptibility Testing #Probiotics and Fermented Foods

paper · doi:10.1128/aem.00744-21

openalex publication_date 2021/06/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is an uncommon cause of urinary tract infections (UTI) in the general population. However, it is important to understand MRSA pathophysiology in the urinary tract because isolation of MRSA in urine samples often precedes potentially life-threatening MRSA bacteremia. In this report, we describe how exposure to human urine alters MRSA global gene expression and virulence. We hypothesize that these alterations may aid MRSA in acclimating to the nutrient-limiting, immunologically hostile conditions within the urinary tract leading to MRSA UTI.

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