Antimicrobial Effect of Chitosan Nanoparticles on Streptococcus mutans Biofilms

2011/06/01 by Luis E. Chávez de Paz, Anton Resin, Kenneth A. Howard +2

paper · doi:10.1128/aem.02941-10

Abstract

ABSTRACT Nanoparticle complexes were prepared from chitosans of various molecular weights (MW) and degrees of deacetylation (DD). The antimicrobial effect was assessed by the Live/Dead BacLight technique in conjunction with confocal scanning laser microscopy (CSLM) and image analysis. Nanocomplexes prepared from chitosans with high MW showed a low antimicrobial effect (20 to 25% of cells damaged), whereas those prepared from low-MW chitosans showed high antimicrobial effect (>95% of cells damaged).

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