Neuronal autophagy and mitophagy in Parkinson's disease

2021/06/12 by Britney N. Lizama, Charleen T. Chu · 1 citation
Medicine · #Autophagy in Disease and Therapy #Parkinson's Disease Mechanisms and Treatments

paper · doi:10.1016/j.mam.2021.100972

Citations

• Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
• α-Synuclein Is Degraded by Both Autophagy and the Proteasome
• PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
• Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells

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