Cell therapy with human interleukin 10–producing ILC2s enhances islet function and inhibits allograft rejection

2025/05/23 by Sarah J. Colpitts, Sinthuja Jegatheeswaran, Amanda Oakie +16 · 3 voices
Immunology and Microbiology · Medicine · #IL-33, ST2, and ILC Pathways #Pancreatic function and diabetes #Immune Cell Function and Interaction

paper · pdf · doi:10.1016/j.ajt.2025.05.023

Citations

• Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models

Discussions

• 🧬 Excited to share our latest study now In Press: In this study led by rising star @sarahcolpitts.bsky.social, we show that IL-10⁺ #ILC2s prevent rejection and improve islet graft survival and functi [bsky, 16 points, 1 comments]
• 🎉Excited to share our recently online pre-print of our study showing human IL-10+ILC2s have cell therapy potential to improve islet transplant by suppressing graft rejection. Many thanks to all our c [bsky, 12 points, 0 comments]
• Article in Press AND Open Access! "Cell therapy with human IL-10-producing ILC2s enhances islet function and inhibits allograft rejection" by Colpitts et al. doi.org/10.1016/j.aj... @sarahcolpitts.bsk [bsky, 4 points, 1 comments]