2025/03/14 by Rossa, Lea Antonia, Wei, Huimin, Lemcke, Heiko +2
#MPS #superparamagnetic iron oxide nanoparticles (SPIONs)
paper · doi:10.18416/ijmpi.2025.2503050
Superparamagnetic iron oxide nanoparticles (SPIONs) have a significant role in biomedical applications such as hyperthermia therapy or magnetic particle imaging. This study investigates the loading of 3D cell spheroids made from a pancreas cell line of rats with magnetic nanoparticles. Here, we show the uptake and a homogeneous distribution of nanoparticles in spheroids, while magnetic particle spectrometry (MPS) reveals a measurable difference in the magnetic behavior of nanoparticles in aqueous solution compared to those incorporated into spheroids.