Characterization and comparison of temperature-sensitive Schizosaccharomyces pombe mutants of the septation initiation network scaffolds, Cdc11 and Sid4

2025/01/07 by Lesley A Turner, Anna Bowman Fletcher, Alaina H. Willet +1 · 1 voice
Biochemistry, Genetics and Molecular Biology · #RNA Research and Splicing #Ubiquitin and proteasome pathways #Viral Infectious Diseases and Gene Expression in Insects

paper · doi:10.17912/micropub.biology.001503

openalex publication_date 2025/01/07 · openalex created_date 2025/03/05 · openalex updated_date 2026/08/01

Abstract

mutants isolated in the 1990s. We determined the mutations within each allele, examined their phenotypes, and analyzed their growth compared with previously characterized mutant alleles. The new mutants described here expand the toolkit for studying how the SIN assembles at SPBs.

Citations

• Heterologous modules for efficient and versatile PCR-based gene targeting inSchizosaccharomyces pombe
• Accurate structure prediction of biomolecular interactions with AlphaFold 3

Discussions

• 🔬 Scientists have identified key mutations in fission yeast that affect the assembly of proteins needed for cell division. These findings help us better understand the complex process of cytokinesis. [bsky, 0 points, 0 comments]

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