The Geographic Origin of Helicobacter pylori Influences the Association of the homB Gene with Gastric Cancer

2011/12/29 by Jieun Kang, Kathleen R. Jones, Sungil Jang +7
Medicine · Immunology and Microbiology · Veterinary · #Helicobacter pylori-related gastroenterology studies #Galectins and Cancer Biology #Veterinary medicine and infectious diseases

paper · pdf · doi:10.1128/jcm.06293-11

Abstract

We found that South Korean Helicobacter pylori isolates predominantly carry homB at locus B and that there is no association between the homB allele and the cagA allele or the development of gastric cancer within this population. Uniquely, several East Asian strains carried multiple copies of the hom genes.

Citations

• homB Status of Helicobacter pylori as a Novel Marker To Distinguish Gastric Cancer from Duodenal Ulcer
• Epidemiological Link between Gastric Disease and Polymorphisms in VacA and CagA
• Polymorphism in the CagA EPIYA Motif Impacts Development of Gastric Cancer

Related

• Helicobacter pylori homB , but Not cagA , Is Associated with Gastric Cancer in Iran
• homB Status of Helicobacter pylori as a Novel Marker To Distinguish Gastric Cancer from Duodenal Ulcer
• Diverse Characteristics of the cagA Gene of Helicobacter pylori Strains Collected from Patients from Southern Vietnam with Gastric Cancer and Peptic Ulcer
• Polymorphism in the CagA EPIYA Motif Impacts Development of Gastric Cancer
• Fine-scale population structure of Japanese Helicobacter pylori provides new anthropological and epidemiological insights