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Overview of Changes to the Clinical and Laboratory Standards Institute <i>Performance Standards for Antimicrobial Susceptibility Testing,</i> M100, 31st Edition

2021/09/22 by Romney Humphries, April M. Bobenchik, Janet A. Hindler +1 · 8 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Antibiotic Use and Resistance #Antibiotics Pharmacokinetics and Efficacy #Bacterial Identification and Susceptibility Testing

paper · doi:10.1128/jcm.00213-21

openalex publication_date 2021/09/22 · openalex created_date 2021/09/27 · openalex updated_date 2026/07/31

Abstract

, Pseudomonas aeruginosa, and anaerobes), and lefamulin (Staphylococcus aureus, Haemophilus influenzae, and Streptococcus pneumoniae), and disk breakpoints are described for azithromycin and Neisseria gonorrhoeae. The rationale behind revised oxacillin MIC breakpoints for select staphylococci is discussed. Updates to test methods include a method for disk diffusion using positive blood culture broth and use of linezolid to predict tedizolid susceptibility. There is clarification on which drugs to suppress on bacteria isolated from the cerebrospinal fluid and clarification on the use of a caret symbol attached to the intermediate category ("I^") to indicate those antimicrobials that concentrate in the urine.

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