2019/01/11 by Elodie Laridan, Kimberly Martinod, Simon De Meyer +1 · 287 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Biology #Cardiology #Cell biology #Coagulation #Deep vein #Extracellular #Inflammation #Internal medicine #Medicine #Neutrophil extracellular traps #Neutrophil, Myeloperoxidase and Oxidative Mechanisms #Platelet #Platelet activation #Protease and Inhibitor Mechanisms #S100 Proteins and Annexins #Stroke (engine) #Thrombosis #Thrombus #Venous thrombosis
paper · open access · doi:10.1055/s-0038-1677040
published in Seminars in Thrombosis and Hemostasis 45(01), 086-093 (Thieme Medical Publishers (Germany))
openalex publication_date 2019/01/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Thrombotic complications are still a major health risk worldwide. Our view on the pathophysiology of thrombosis has significantly changed since the discovery of neutrophil extracellular traps (NETs) and their prothrombotic characteristics. Generated by neutrophils that release their decondensed chromatin as a network of extracellular fibers, NETs promote thrombus formation by serving as a scaffold that activates platelets and coagulation. The thrombogenic involvement of NETs has been described in various settings of thrombosis, including stroke, myocardial infarction, and deep vein thrombosis. The aim of this review is to summarize existing evidence showing the presence of NETs in human thrombus material. Following an introduction on NETs and their role in thrombus formation, the authors address studies showing the presence of NETs in arterial or venous thrombi. In addition, they focus on potential novel therapeutic opportunities to resolve or prevent thrombosis by targeting NETs.