Long-term physical stability of amorphous solid dispersions: Comparison of detection powers of common evaluation methods for spray-dried and hot-melt extruded formulations

2025/06/28 by Kohsaku Kawakami, Taichi Ishitsuka, Masafumi Fukiage +8
#Amorphous solid dispersion #Crystallization #Dissolution study #Stability

paper · doi:10.48505/nims.5522

Abstract

Journal of Pharmaceutical Sciences. 114 [1] (2024)145-156

Related

• Guiding excipient selection for physically stable amorphous solid dispersions: A combined in-vitro in-silico approach
• Guiding excipient selection for physically stable amorphous solid dispersions: A combined in-vitro in-silico approach
• Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies
• Excipient variability critically impacts crystallization propensity of spray-dried amorphous solid dispersions
• Overcoming drug impurity challenges in amorphous solid dispersion with rational development of biorelevant dissolution-permeation method