The Janus face of phase II drug-metabolizing enzymes in hypoxia: guardian of antioxidant defense or accomplice in metabolic disorders?

2026/05/14 by Yawen Xin, Qian Wang, Sencai Wang +5
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Biochemical Acid Research Studies #Cancer, Hypoxia, and Metabolism #Pharmacogenetics and Drug Metabolism

paper · doi:10.1016/j.dmd.2026.100326

openalex publication_date 2026/05/14 · openalex created_date 2026/05/15 · openalex updated_date 2026/07/31

Citations

• FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity
• Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
• A STUDY OF SOME PROPERTIES OF EXCITED STATES IN LIGHT NUCLEI USING HELIUM-3-INDUCED REACTIONS