2015/02/12 by Klaus Zangger · 332 citations
Chemistry · Physics and Astronomy · #Advanced NMR Techniques and Applications #Carbon-13 NMR satellite #Chemical shift #Chemistry #Decoupling (probability) #Fluorine-19 NMR #Homonuclear molecule #Molecular spectroscopy and chirality #Molecule #Multiplet #NMR spectra database #NMR spectroscopy and applications #Nuclear magnetic resonance #Nuclear magnetic resonance spectroscopy #Organic chemistry #Physical chemistry #Physics #Proton #Proton NMR #Spectral line #Stereochemistry #Two-dimensional nuclear magnetic resonance spectroscopy
paper · pdf · doi:10.1016/j.pnmrs.2015.02.002
published in Progress in Nuclear Magnetic Resonance Spectroscopy 86-87, 1-20 (Elsevier BV)
openalex publication_date 2015/02/12 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/05
Although scalar-coupling provides important structural information, the resulting signal splittings significantly reduce the resolution of NMR spectra. Limited resolution is a particular problem in proton NMR experiments, resulting in part from the limited proton chemical shift range (∼10 ppm) but even more from the splittings due to scalar coupling to nearby protons. "Pure shift" NMR spectroscopy (also known as broadband homonuclear decoupling) has been developed for disentangling overlapped proton NMR spectra. The resulting spectra are considerably simplified as they consist of single lines, reminiscent of proton-decoupled C-13 spectra at natural abundance, with no multiplet structure. The different approaches to obtaining pure shift spectra are reviewed here and several applications presented. Pure shift spectra are especially useful for highly overlapped proton spectra, as found for example in reaction mixtures, natural products and biomacromolecules.