2025/11/04 by Delin Ma, Menghui Zhou, Ma, Delin +7
Computer Science · Medicine · Neuroscience · #Advanced Neural Network Applications #Artificial Intelligence (cs.AI) #Brain Tumor Detection and Classification #Computer Vision and Pattern Recognition (cs.CV) #Dementia and Cognitive Impairment Research #FOS: Computer and information sciences
paper · pdf · doi:10.48550/arxiv.2511.02228
openalex publication_date 2025/11/04 · openalex created_date 2025/11/06 · openalex updated_date 2026/07/28
Alzheimer's disease (AD) is the most prevalent form of dementia, and its early diagnosis is essential for slowing disease progression. Recent studies on multimodal neuroimaging fusion using MRI and PET have achieved promising results by integrating multi-scale complementary features. However, most existing approaches primarily emphasize cross-modal complementarity while overlooking the diagnostic importance of modality-specific features. In addition, the inherent distributional differences between modalities often lead to biased and noisy representations, degrading classification performance. To address these challenges, we propose a Collaborative Attention and Consistent-Guided Fusion framework for MRI and PET based AD diagnosis. The proposed model introduces a learnable parameter representation (LPR) block to compensate for missing modality information, followed by a shared encoder and modality-independent encoders to preserve both shared and specific representations. Furthermore, a consistency-guided mechanism is employed to explicitly align the latent distributions across modalities. Experimental results on the ADNI dataset demonstrate that our method achieves superior diagnostic performance compared with existing fusion strategies.