Fosfomycin Alters Lipopolysaccharide-Induced Inflammatory Cytokine Production in Mice

1999/03/01 by Tetsuya Matsumoto, Kazuhiro Tateda, Shuichi Miyazaki +5 · 1 citation
Immunology and Microbiology · #Immune Response and Inflammation #Neutrophil, Myeloperoxidase and Oxidative Mechanisms #Reproductive System and Pregnancy

paper · pdf · doi:10.1128/aac.43.3.697

Abstract

To determine the mechanisms of immunomodulating action of fosfomycin (FOF), we examined its effect on the production of inflammatory cytokines in mice injected with lipopolysaccharide (LPS). Treatment with FOF significantly lowered the peak serum levels of tumor necrosis factor alpha and interleukin-1 beta, indicating that FOF alters inflammatory cytokine production after LPS stimulation.

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• Fosfomycin as an adjunctive agent against carbapenem-resistant Acinetobacter baumannii: an updated narrative review

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