In Vitro Potency and In Vivo Efficacy of a Novel Bis-Indole Antimicrobial Compound in Reducing Catheter Colonization

2012/01/24 by Mohammad D. Mansouri, Timothy J. Opperman, John D. Williams +3
Health Professions · Medicine · Engineering · #Central Venous Catheters and Hemodialysis #Antibiotics Pharmacokinetics and Efficacy #Mechanical Circulatory Support Devices

paper · pdf · doi:10.1128/aac.05521-11

Abstract

Vascular catheters coated with a novel antimicrobial agent (MBX1631) were studied for their ability to protect against bacterial colonization in vitro and in a rabbit model. MBX1631-coated catheters were significantly less likely to become colonized than control catheters both in vitro and in vivo (P < 0.001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005).

Citations

• Prolonged Antimicrobial Activity of a Catheter Containing Chlorhexidine-Silver Sulfadiazine Extends Protection against Catheter Infections In Vivo

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