Impact of Acquired Broad-Spectrum β-Lactamases on Susceptibility to Cefiderocol and Newly Developed β-Lactam/β-Lactamase Inhibitor Combinations in Escherichia coli and Pseudomonas aeruginosa

2022/03/22 by Laurent Poirel, Jose-Manuel Ortiz de la Rosa, José Manuel Ortiz de la Rosa +2 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Immunology and Microbiology · #Antibiotic Resistance in Bacteria #Antibiotics Pharmacokinetics and Efficacy #Antibiotic Use and Resistance

paper · doi:10.1128/aac.00039-22

Abstract

The ability of broad-spectrum β-lactamases to reduce the susceptibility to ceftazidime-avibactam (CZA), ceftolozane-tazobactam (C/T), imipenem-relebactam, meropenem-vaborbactam, aztreonam-avibactam (AZA), and cefiderocol (FDC) was evaluated both in Pseudomonas aeruginosa and in Escherichia coli using isogenic backgrounds. Although metallo-β-lactamases conferred resistance in most cases, except for AZA, several clavulanic-acid-inhibited extended-spectrum β-lactamases (PER, BEL, SHV) had a significant impact on the susceptibility to CZA, C/T, and FDC.

Cited by

• Environmental reservoir of resistance genes for the last resort antibiotic Cefiderocol
• Influence of PER-7 on cefiderocol susceptibility in clinical isolates of Acinetobacter baumannii producing OXA-23 or OXA-72 carbapenemases

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