Widespread Dissemination of CTX-M-15 Genotype Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae among Patients Presenting to Community Hospitals in the Southeastern United States

2013/11/19 by Luke F. Chen, Joshua T. Freeman, Brad Nicholson +12 · 1 citation
Biochemistry, Genetics and Molecular Biology · Environmental Science · #Antibiotic Resistance in Bacteria #Biology #Enterobacteriaceae #Enterobacteriaceae and Cronobacter Research #Escherichia coli #Gene #Genetics #Genotype #Klebsiella pneumoniae #Microbiology #Pharmaceutical and Antibiotic Environmental Impacts

paper · pdf · doi:10.1128/aac.01099-13

openalex publication_date 2013/11/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Extended-spectrum-β-lactamase (ESBL)-producing organisms are increasingly prevalent. We determined the characteristics of 66 consecutive ESBL-producing isolates from six community hospitals in North Carolina and Virginia from 2010 to 2012. Fifty-three (80%) ESBL-producing isolates contained CTX-M enzymes; CTX-M-15 was found in 68% of Escherichia coli and 73% of Klebsiella isolates. Sequence type 131 (ST131) was the commonest type of E. coli, accounting for 48% of CTX-M-15-producing and 66% of CTX-M-14-producing isolates. In conclusion, the CTX-M genotype and ST131 E. coli were common among ESBL isolates from U.S. community hospitals.

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• Tackling drug resistant infection outbreaks of global pandemic\n Escherichia coli ST131 using evolutionary and epidemiological genomics

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