2020/10/28 by Myungjin Kim, Allison H. Kowalsky, Jun Hee Lee
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cell biology #Context (archaeology) #Endocrinology #Genomics, phytochemicals, and oxidative stress #Homeostasis #Hormesis #Mediator #Oxidative stress #PI3K/AKT/mTOR signaling in cancer #Protein kinase B #Signal transduction #Sirtuins and Resveratrol in Medicine #Skeletal muscle
paper · doi:10.1146/annurev-physiol-031620-092317
openalex publication_date 2020/10/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Sestrins are a family of proteins that respond to a variety of environmental stresses, including genotoxic, oxidative, and nutritional stresses. Sestrins affect multiple signaling pathways: AMP-activated protein kinase, mammalian target of rapamycin complexes, insulin-AKT, and redox signaling pathways. By regulating these pathways, Sestrins are thought to help adapt to stressful environments and subsequently restore cell and tissue homeostasis. In this review, we describe how Sestrins mediate physiological stress responses in the context of nutritional and chemical stresses (liver), physical movement and exercise (skeletal muscle), and chemical, physical, and inflammatory injuries (heart). These findings also support the idea that Sestrins are a molecular mediator of hormesis, a paradoxical beneficial effect of low- or moderate-level stresses in living organisms.