HEAT-SHOCK PROTEINS, MOLECULAR CHAPERONES, AND THE STRESS RESPONSE: Evolutionary and Ecological Physiology

1999/03/01 by Martin E. Feder, Gretchen E. Hofmann · 4,326 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Environmental Science · #Biology #Cell biology #Context (archaeology) #Evolutionary biology #Function (biology) #Gene #Genetics #Heat shock protein #Heat shock proteins research #Multicellular organism #Phenotype #Physiological and biochemical adaptations #thermodynamics and calorimetric analyses

paper · doi:10.1146/annurev.physiol.61.1.243

published in Annual Review of Physiology 61(1), 243-282 (Annual Reviews)

openalex publication_date 1999/03/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/06

Abstract

Molecular chaperones, including the heat-shock proteins (Hsps), are a ubiquitous feature of cells in which these proteins cope with stress-induced denaturation of other proteins. Hsps have received the most attention in model organisms undergoing experimental stress in the laboratory, and the function of Hsps at the molecular and cellular level is becoming well understood in this context. A complementary focus is now emerging on the Hsps of both model and nonmodel organisms undergoing stress in nature, on the roles of Hsps in the stress physiology of whole multicellular eukaryotes and the tissues and organs they comprise, and on the ecological and evolutionary correlates of variation in Hsps and the genes that encode them. This focus discloses that (a) expression of Hsps can occur in nature, (b) all species have hsp genes but they vary in the patterns of their expression, (c) Hsp expression can be correlated with resistance to stress, and (d) species' thresholds for Hsp expression are correlated with levels of stress that they naturally undergo. These conclusions are now well established and may require little additional confirmation; many significant questions remain unanswered concerning both the mechanisms of Hsp-mediated stress tolerance at the organismal level and the evolutionary mechanisms that have diversified the hsp genes.

Citations

• Thermotolerance of a Long-lived Mutant of Caenorhabditis elegans

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