Interorgan Communication Pathways in Physiology: Focus on <i>Drosophila</i>

2016/10/12 by Ilia A. Droujinine, Norbert Perrimon · 8 citations
Neuroscience · Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Neurobiology and Insect Physiology Research #Genetics, Aging, and Longevity in Model Organisms #Invertebrate Immune Response Mechanisms

paper · pdf · doi:10.1146/annurev-genet-121415-122024

Abstract

Studies in mammals and Drosophila have demonstrated the existence and significance of secreted factors involved in communication between distal organs. In this review, primarily focusing on Drosophila, we examine the known interorgan communication factors and their functions, physiological inducers, and integration in regulating physiology. Moreover, we describe how organ-sensing screens in Drosophila can systematically identify novel conserved interorgan communication factors. Finally, we discuss how interorgan communication enabled and evolved as a result of specialization of organs. Together, we anticipate that future studies will establish a model for metazoan interorgan communication network (ICN) and how it is deregulated in disease.

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