2018/01/12 by Dario Neri, Richard A. Lerner · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Advanced biosensing and bioanalysis techniques #Biochemistry #Biology #Chemical Synthesis and Analysis #Chemical biology #Chemistry #Combinatorial chemistry #Computational biology #Computer science #DNA #DNA sequencing #Drug discovery #Genetics #Materials science #Monoclonal and Polyclonal Antibodies Research #Nanotechnology
paper · pdf · doi:10.1146/annurev-biochem-062917-012550
openalex publication_date 2018/01/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06
The discovery of organic ligands that bind specifically to proteins is a central problem in chemistry, biology, and the biomedical sciences. The encoding of individual organic molecules with distinctive DNA tags, serving as amplifiable identification bar codes, allows the construction and screening of combinatorial libraries of unprecedented size, thus facilitating the discovery of ligands to many different protein targets. Fundamentally, one links powers of genetics and chemical synthesis. After the initial description of DNA-encoded chemical libraries in 1992, several experimental embodiments of the technology have been reduced to practice. This review provides a historical account of important milestones in the development of DNA-encoded chemical libraries, a survey of relevant ongoing research activities, and a glimpse into the future.