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Optimal multiple testing under family-wise error control: elementary symmetric polynomials and a scalable algorithm

2026/04/13 by Prasanjit Dubey, Xiaoming Huo
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Abstract

Family-wise error rate control is essential when even one false rejection is costly, but distribution-free procedures do not exploit information in a specified alternative model. Existing dual theory characterises the maximum-average-power procedure under strong family-wise error control, but its optimal multipliers had been computed only up to K = 3. Under an exchangeable product model of independent p-values with a common non-increasing density under the alternative, we develop a general-K statistical methodology that removes this computational barrier. An elementary-symmetric-polynomial representation yields global monotonicity of every constraint function and converts the coupled multiplier problem into monotone coordinate-wise searches. The resulting algorithm, symmetric-polynomial optimal testing (SPOT), uses bisection coordinate descent and has polynomial per-sweep cost in K and the Monte Carlo size. Under stated conditions, its exact population objective values converge to the optimum and every limit point is optimal, without contraction or strong-convexity assumptions. Additional local regularity gives linear convergence of the exact population iterates, and an achieved Op(N-1/2) residual gives √(N)-consistent Monte Carlo output. In a truncated-normal scaling experiment, the relative average-power gain over Hommel's method increases from 15% at K = 3 to 83% at K = 12. Applications with up to 21 hypotheses demonstrate SPOT's practical reach.

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